Seto Group
Recent Publications
             

1. “Modular Ligands Derived from Amino Acids for the Enantioselective Addition of Organozinc Reagents to Aldehydes” Richmond, M. L.; Seto, C. T. Submitted.


2.


“Chiral N-Acyl-ethylenediamines as New Modular Ligands for the Catalytic Asymmetric Addition of Alkylzinc Reagents to Aldehydes” Sprout, C. M.; Seto, C. T. Submitted.

3.


“Peptidic a-Ketocarboxylic Acids and Sulfonamides as Inhibitors of Protein Tyrosine Phosphatases” Chen, Y. T.; Xie, J.; Seto, C. T. J. Org. Chem. 2003, 68, 4123. Full Paper


4.


“Divalent and Trivalent a-Ketocarboxylic Acids as Inhibitors of Protein Tyrosine Phosphatases” Chen, Y. T.; Seto, C. T. J. Med. Chem. 2002, 45, 3946. Full Paper

5.

“Inhibitors of Plasmin that Extend into Both the S and S’ Binding Sites: Cooperative Interactions Between S1 and S2” Abato, P.; Yuen, C. M.; Cubanski, J. Y.; Seto, C. T. J. Org. Chem. 2002, 67, 1184. Full Paper

6.

“EMDee: An Enzymatic Method for Determining Enantiomeric Excess” Abato, P.; Seto, C. T. J. Am. Chem. Soc. 2001, 123, 9206. Full Paper

7.

“a-Ketocarboxylic Acid-Based Inhibitors of Protein Tyrosine Phosphatases” Chen, Y. T.; Onaran, M. B.; Doss, C. J.; Seto, C. T. Bioorg. Med. Chem. Lett. 2001, 11, 1935. Full Paper

8.

“Biotinylation of Substituted Cysteines in the Nicotinic Acetylcholine Receptor Reveals Distinct Binding Modes for a-Bungarotoxin and Erabutoxin a” Spura, A.; Riel, R. U.; Freedman, N. D.; Agrawal, S.; Seto, C. T.; Hawrot, E. J. Biol. Chem. 2000, 275, 22452. Full Paper

9.

“The Effects of Buffers on the Thermodynamics and Kinetics of Binding Between Positively-Charged Cyclodextrins and Phosphate Ester Guests” Ghosh, M.; Zhang, R.; Lawler, R. G.; Seto, C. T. J. Org. Chem. 2000, 65, 735. Full Paper

10.

“Inhibition of Phosphatase Activity by Positively-Charged Cyclodextrins” Ghosh, M.; Sanders, C. T.; Zhang, R.; Seto, C. T. Org. Lett. 1999, 1, 1945. Full Paper


11.


“A Combinatorial Library of Serine and Cysteine Protease Inhibitors that Interact with Both the S and S’ Binding Sites” Abato, P.; Conroy, J. L.; Seto, C. T. J. Med. Chem. 1999, 42, 4001. Full Paper

12.

“4-Heterocyclohexanone-Based Inhibitors of the Serine Protease Plasmin” Sanders, T. C.; Seto, C. T. J. Med. Chem. 1999, 42, 2969. Full Paper


13.


“Hydrolysis of Amides Catalyzed by 4-Heterocyclohexanones: Small Molecule Mimics of Serine Proteases” Ghosh, M.; Conroy, J. L.; Seto, C. T. Angew. Chemie. Int. Ed. Engl. 1999, 38, 514 - 516. Full Paper


14.

“Synthesis of Cyclohexanone-Based Cathepsin B Inhibitors that Interact with Both the S and S’ Binding Sites” Conroy, J. L.; Abato, P.; Ghosh, M.; Austermuhle, M. I.; Kiefer, M. R.; Seto, C. T. Tetrahedron Lett. 1998, 39, 8253 - 8256. Full Paper

15.

“13C NMR Studies Demonstrate that Tetrahydropyranone-Based Inhibitors Bind to Cysteine Proteases by Reversible Formation of a Hemithioketal Adduct” Conroy, J. L.; Seto, C. T., J. Org. Chem. 1998, 63, 2367. Full Paper

16.

“Using the Electrostatic Field Effect to Design a New Class of Inhibitors for Cysteine Proteases” Conroy, J. L.; Sanders, T. C.; Seto, C. T. J. Am. Chem. Soc. 1997, 119, 4285. Full Paper